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Zhiguo Zhang Selected Research

Type 2 Diabetes Mellitus (MODY)

11/2020Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
1/2020Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function.
1/2020Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function.
11/2019Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy.
1/20194-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.
1/2017Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy.
10/2016Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease.
12/2015Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2.
7/2014Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function.
1/2014Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.
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Zhiguo Zhang Research Topics

Disease

28Neoplasms (Cancer)
11/2021 - 09/2008
27Inflammation (Inflammations)
10/2021 - 09/2011
15Fibrosis (Cirrhosis)
01/2022 - 01/2014
15Obesity
11/2020 - 01/2008
15Insulin Resistance
01/2020 - 08/2007
12Genomic Instability
01/2018 - 07/2008
11Atherosclerosis
03/2021 - 09/2011
11Type 2 Diabetes Mellitus (MODY)
11/2020 - 01/2012
11Hyperglycemia
07/2020 - 07/2014
10Atherosclerotic Plaque (Atheroma)
01/2021 - 10/2010
9Carcinogenesis
01/2022 - 07/2011
9Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2018 - 09/2014
8Hypoxia (Hypoxemia)
01/2022 - 10/2013
8Non-alcoholic Fatty Liver Disease
01/2021 - 01/2014
8Diabetic Cardiomyopathies
01/2020 - 10/2014
7Pain (Aches)
02/2022 - 01/2014
7Cardiovascular Diseases (Cardiovascular Disease)
03/2021 - 01/2008
7Glioma (Gliomas)
01/2021 - 01/2013
6Cardiomyopathies (Cardiomyopathy)
01/2020 - 12/2014
6Body Weight (Weight, Body)
10/2016 - 01/2008
5Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
10/2021 - 10/2008
5Necrosis
08/2020 - 01/2010
4Fatty Liver
01/2021 - 03/2015
4Brain Neoplasms (Brain Tumor)
01/2021 - 01/2016
4Glioblastoma (Glioblastoma Multiforme)
01/2021 - 01/2016
4Alveolar Bone Loss
07/2020 - 12/2014
4Infections
02/2020 - 06/2013
4Wounds and Injuries (Trauma)
01/2018 - 03/2012
4Cardiomegaly (Heart Hypertrophy)
08/2017 - 01/2014
4Osteoporosis
04/2016 - 01/2012
3Dehydration (Water Stress)
04/2022 - 01/2020
3COVID-19
02/2022 - 07/2020
3Infertility (Sterility)
01/2022 - 02/2016
3Ovarian Neoplasms (Ovarian Cancer)
11/2021 - 06/2016
3Myocardial Ischemia (Ischemic Heart Diseases)
03/2021 - 12/2018
3Neoplasm Metastasis (Metastasis)
04/2020 - 01/2019
3Male Infertility (Male Sterility)
04/2020 - 03/2015
3Hypertrophy
01/2020 - 09/2016
3Diabetic Nephropathies (Diabetic Nephropathy)
01/2020 - 12/2015
3ST Elevation Myocardial Infarction
01/2020 - 01/2018
3Hyperplasia
01/2020 - 01/2010
3Diffuse Intrinsic Pontine Glioma
12/2019 - 01/2016
3Infarction (Infarctions)
09/2019 - 01/2013
3Hepatocellular Carcinoma (Hepatoma)
01/2019 - 09/2014
3Chondroblastoma
01/2018 - 06/2016
2Heart Failure
07/2022 - 09/2010

Drug/Important Bio-Agent (IBA)

18LipidsIBA
10/2021 - 01/2014
15Histones (Histone)IBA
12/2019 - 06/2009
14Proteins (Proteins, Gene)FDA Link
04/2022 - 10/2009
12sulforaphaneIBA
01/2020 - 01/2014
10Streptozocin (Streptozotocin)FDA Link
01/2020 - 01/2014
9Biomarkers (Surrogate Marker)IBA
01/2022 - 06/2013
9MetallothioneinIBA
01/2019 - 03/2015
8MicroRNAs (MicroRNA)IBA
07/2020 - 09/2008
8Glucose (Dextrose)FDA LinkGeneric
01/2020 - 08/2007
8Lysine (L-Lysine)FDA Link
12/2019 - 06/2009
8Nucleosomes (Nucleosome)IBA
01/2018 - 10/2009
7ZincIBA
01/2019 - 03/2015
6DNA (Deoxyribonucleic Acid)IBA
10/2021 - 03/2012
61-phenyl-3,3-dimethyltriazene (PDT)IBA
08/2020 - 01/2010
5Pharmaceutical PreparationsIBA
02/2022 - 07/2014
5CytokinesIBA
01/2021 - 01/2016
5Biological ProductsIBA
04/2020 - 07/2012
5AntioxidantsIBA
01/2020 - 10/2014
5Reactive Oxygen Species (Oxygen Radicals)IBA
09/2019 - 01/2008
5Insulin (Novolin)FDA Link
07/2017 - 08/2007
4Transcription Factors (Transcription Factor)IBA
01/2022 - 09/2016
4Phosphotransferases (Kinase)IBA
10/2021 - 01/2008
4Therapeutic UsesIBA
01/2021 - 06/2013
4oxidized low density lipoproteinIBA
01/2020 - 11/2015
4Methionine (L-Methionine)FDA Link
12/2019 - 01/2016
4CurcuminIBA
01/2019 - 10/2012
4ChromatinIBA
11/2018 - 07/2008
4p38 Mitogen-Activated Protein KinasesIBA
01/2017 - 12/2014
4protoporphyrin IXIBA
12/2014 - 01/2010
3RNA (Ribonucleic Acid)IBA
11/2021 - 01/2016
3Circular RNAIBA
10/2021 - 01/2020
3NF-kappa B (NF-kB)IBA
10/2021 - 01/2008
3HMGB1 Protein (HMG1)IBA
01/2021 - 01/2020
3BerberineIBA
11/2020 - 01/2012
3DiosgeninIBA
07/2020 - 09/2014
3AcidsIBA
01/2020 - 01/2011
3Fatty Acids (Saturated Fatty Acids)IBA
01/2020 - 01/2019
3dipinacoline glutamateIBA
12/2019 - 01/2016
34-O-methylhonokiolIBA
01/2019 - 01/2014
3CholesterolIBA
01/2018 - 01/2011
3Mutant Proteins (Protein, Mutant)IBA
01/2018 - 06/2016
3fibroblast growth factor 21IBA
01/2017 - 07/2015
3Triglycerides (Triacylglycerol)IBA
11/2015 - 01/2008
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2015 - 01/2011

Therapy/Procedure

18Therapeutics
01/2022 - 06/2013
9Ovariectomy (Oophorectomy)
07/2020 - 01/2012
6Photochemotherapy (Photodynamic Therapy)
08/2020 - 01/2010
5Lasers (Laser)
01/2022 - 06/2013
5Stents
06/2020 - 01/2018
3Pain Management
02/2022 - 12/2019
3Drug Therapy (Chemotherapy)
03/2021 - 06/2013
3Drug-Eluting Stents
06/2020 - 11/2019
3Intraperitoneal Injections
01/2020 - 07/2014
3Percutaneous Coronary Intervention
01/2020 - 01/2018